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the goal is to steadily replenish deep tissue stores over weeks and months, slowly shifting the cellular environment from a state of emergency to a state of repair

1996 Jul;48(5):439-46

This is why combining both pathways (as in CagriSema) produces greater weight loss than either alone

Individuals may experience symptoms such as fatigue (often manifesting as that all too familiar tired but wired feeling), poor quality sleep , as well as a poor ability to handle stress

doi: 10.1016/j.pnpbp.2006.04.012 121 PatrignaniPTacconelliS

Thoene J, Lemons R, Anikster Y, Mullet J, Paelicke K, Lucero C, Gahl W, Schneider J, Shu SG, Campbell HT (1999) Mutations of CTNS causing intermediate cystinosis