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Stem cell niches may reactivate in cleared tissue Months 1-6+: Gradual tissue remodeling and functional recovery in organs where senescent cell burden was reduced This cascade explains why FOXO4-DRI doesn't produce immediate, obvious effects

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Commun Soil Sci Plant Anal 52:743755

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This may lead to subsequent physiological abnormalities including gut dysbiosis and systemic inflammation, eventually resulting in a pathological clotting system, chronic endothelialitis, vasoconstriction, and hypoxia, as found in similar conditions such as heat stroke (183)

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