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However, the translation to clinical efficacy in human osteoarthritis remains ambiguous, as weight loss appears to play a substantial role in pain alleviation [21, 22]

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doi: 10.1016/j.canlet.2005.02.033

However, they are considered to be more effective than oral supplements as they facilitate the direct delivery of compounds into the bloodstream, and by extension, into the skin and other target organs by skipping the digestive process

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