There lies a narrow physiochemical window for the drug to effectively pass the stratum corneum which includes low melting point, low molecular weight of 600 Da, and water/octanol partition coefficient in the range of 13 [216]
The protective effects of cryptochlorogenic acid on beta-cells function in diabetes in vivo and vitro via inhibition of ferroptosis
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The tissue was homogenized thrice at 1500 rpm for 120 s using a tissue homogenizer (Micro Smash MS100R, Tomy Digital Biology Co., Ltd., Tokyo, Japan) following which the homogenate was centrifuged at 2300 g and 4 C for 5 min
DHA and EPA prevent seizure and depression-like behavior by inhibiting ferroptosis and neuroinflammation via different mode-of-actions in a pentylenetetrazole-induced kindling model in mice
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