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However, some patients report musculoskeletal discomfort, which may relate to rapid weight loss, dehydration, or increased physical activity rather than direct medication effects

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Additionally, there have been rare reports of non-arteritic anterior ischaemic optic neuropathy (NAION) in observational studies of semaglutide, though a causal relationship has not been established and regulatory authorities continue to monitor this signal

Elevated temperatures accelerate all chemical reaction rates, including hydrolysis and oxidation

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