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Baroni L, Goggi S, Battaglino R et al

About SELECT clinical study SELECT (Semaglutide Effects on Cardiovascular Outcomes in People With Overweight or Obesity) is a randomised, double-blind, parallel-group, placebo-controlled trial designed to evaluate the efficacy of semaglutide 2.4 mg versus placebo as an adjunct to standard of care for the prevention of major adverse cardiac events (MACE) in people with overweight or obesity and established cardiovascular disease with no prior history of diabetes

While short-term imaging rarely shows dramatic bone density change, longer-term studies may reveal subtle shifts

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Comparing the anchor chemistry across these molecules is one of the clearer ways to see how small lipid and linker changes translate into large pharmacokinetic differences