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Patients who are already on basal insulin like Lantus and want a more concentrated option with potentially fewer injection-site reactions and slightly lower hypoglycemia risk
Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase
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Using rodent models of obesity and metabolic dysfunction, the research group demonstrated that the triple-agonist approach produced meaningful reductions in body weight and improved glycaemic parameters compared to both placebo and comparator compounds targeting fewer receptors
doi: 10.1136/gut.2004.059741 13 UssherJRDruckerDJ
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