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Ultrastructure analysis shows that when ferroptosis occurs,cell membrane rupture and bubbles occur, mitochondria decrease, mitochondria atrophy, the mitochondrial spine decreases or even disappears, and mitochondrial membrane density increases, possibly due to dysfunction of varistor anion channels (VDACs) and alterations in the fluidity of mitochondrial membranes [45]

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Eur J Med Genet 1(71):104962 Maruo Y, Nakahara S, Yanagi T, Nomura A, Mimura Y, Matsui K et al (2016) Genotype of UGT1A1 and phenotype correlation between CriglerNajjar syndrome type II and Gilbert syndrome

Continuous Expansion of Research and Application Scenarios At present, its application has been extended to fields such as cellular antiaging and neuroprotection

The indirect mechanisms consist of modulating gene expression and intracellular signaling pathways, promoting the activation and synthesis of endogenous antioxidant enzymes [38]

Other studies suggest that it might help patients with diabetes