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Despite promising Phase 2 results and an excellent safety profile, the compound could not demonstrate sufficient efficacy in the larger confirmatory trial to justify the investment required for continued pharmaceutical development toward regulatory approval

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What is the recommended timeframe for a second Vitamin B12 injection after an initial dose for borderline low levels?

The greatest IOP change induced by caffeine intake was reached after 90 min from capsule ingestion, being more accentuated for the low-caffeine consumers (+ 3.4 mmHg) than for the high-caffeine consumers (+ 1.2 mmHg)