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PregS potentiates recombinant NMDARs with GluN1-1a/GluN2B through a steroid modulating domain in GluN2B that also modulates tonic proton inhibition and is pH independent

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Mechanism of Action: qualitatively similar to dextroamphetamine compared to amphetamine, the methyl side group present in methamphetamine results in a higher lipid solubility, greater penetration of the blood brain barrier, higher potency with respect to dopamine release, longer half life, and higher potential for abuse and neurotoxicity due to oxidative stress (Yamamoto & Raudensky, 2008