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463,464 It reduces inflammation and improves symptoms primarily by suppressing the effects of TNF- and is typically used in patients who do not respond to or are intolerant to conventional treatments such as 5-aminosalicylic acid

Clinicians must also avoid intravenous administration in the presence of severe sino-atrial, atrioventricular, or intraventricular conduction block in the absence of functional pacemaker support, as well as in classic Adams-Stokes or Wolff-Parkinson-White syndromes, where suppression of accessory pathways may paradoxically precipitate fatal arrhythmias

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Contraindicated in patients with history of pancreatitis

To annotate DVC cell types, as there is no comparable atlas and annotation framework to the hypomap for the DVC, each Leiden cluster was manually annotated into 35 fine-grained cell types (C35 cell type), and were then mapped to the coarser-grained C12 and C2 levels of cell type based on the expression of marker genes

(PubMed) Tan WH, Eichler FS, Hoda S, et al