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The Golgi apparatus hosts various components of the pro- and anti-apoptotic machinery, which indicates that it might be capable of sensing stress signals and thus contribute to the change in the cell fate direction [92]

Currently available pharmacotherapeutics options in HF mostly remain focused on HFrEF, where treatments strategies aim at relief of symptoms, improving quality of life, and prolonging the life of the affected individual (McDonagh et al., 2021

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doi:10.1111/j.1753-4887.2012.00499.x