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If you aren't producing enough bile, fats can move through your system undigested, which often leads to sluggish digestion or constipation

[DOI] [PMC free article] [PubMed] [Google Scholar] 40.Yang WS, SriRamaratnam R, Welsch ME, Shimada K, Skouta R, Viswanathan VS, et al

Don't use tirzepatide if you have severe gastrointestinal disease , such as severe gastroparesis, as it may worsen symptoms due to its effect on gastric emptying

doi: 10.1073/pnas.1612906114 110 MoyaAOrtega-RiberaMGuimerXSowadeEZeaMIllaXet al

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