A research use only label does not automatically remove medicinal status where the wider presentation encourages personal use
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Interestingly, two other studies which enrolled CKD patients with moderately impaired kidney function reported that the sKlotho levels were positively correlated with CAC in coronary artery biopsies (van Venrooij et al., 2014) or AVC in men after adjustment for confounders in the subgroup analysis despite no association in the overall analysis (Morita et al., 2015)
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Besides its impact on cognitive functions, AD is characterized by loss of synapses, extracellular amyloid plaques composed of the amyloid- peptide (A), and intracellular aggregates of hyperphosphorylated Tau protein, accompanied by drastic sleep disorders, sensory function alterations and pain sensitization
Table 1 summarises the characteristics of the included studies
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