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Induction of apoptosis is a major pathwaymany polysaccharides trigger caspase-dependent programmed cell death in tumor cells (131)

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Increased FOXO4 expression correlates with enhanced proteasomal activity, leading to a reduction in the accumulation of damaged proteins, particularly in cardiovascular tissue

But diagnosis itself is a problem, with average delays of 7 to 10 years between symptom onset and confirmation

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