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The most common side effects include: Nausea Constipation or diarrhea Mild fatigue These are often temporary and tend to improve as your body adjusts

This finding is particularly relevant for researchers who ask whether exercise is necessary alongside semaglutide

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Orforglipron's small-molecule structure is significantly less expensive to manufacture than peptide-based injectables like semaglutide and tirzepatide

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The effect typically begins within 4560 minutes after administration and may last for several hours