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In the STEP 1 trial, semaglutide led to an average 14.9% reduction in body weight over 68 weeks , far outperforming placebo (NEJM study on semaglutide for weight loss)

The good news is that most reactions are mild and short-lived: tenderness, a small bruise, or a bit of redness usually settle within 24 to 72 hours

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Direct delivery into the bloodstream ensures maximum benefit

Aging is associated with resistance to effects of leptin on fat distribution and insulin action

There may be state or local laws about how you should throw away (discard) used needles