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At the 12 mg dose level, here is what clinical trials reported: Nausea: 43.2% of participants (versus 10.7% on placebo) Diarrhea: 33.1% of participants (versus 13.4% on placebo) Constipation: 25.0% of participants (versus 8.7% on placebo) Vomiting: 20.9% of participants These percentages tell an important story
Glucagon-like peptide-1 (GLP-1) is a hormone produced in the body that plays a key role in regulating your blood sugar levels
Research has also explored how tri-agonist signaling may affect fat distribution and body composition parameters, including visceral adiposity and total fat mass
The key distinction is the addition of glucagon receptor (GCGR) agonism
52,53 In a phase 2, multi-center trial conducted at 45 centers, orforglipron at doses of 12 mg or greater showed significant reductions in HbA1c and bodyweight compared with placebo or dulaglutide
