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To verify that the PKM2 dimer is a Nrf2 coactivator, we treated astrocytes with DASA-58, a molecule that enhances PKM2 tetramer formation 40
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Brain Health and Cognitive Function Researchers are studying the promising role of glutathione in brain health and its potential in oxidative damage reduction and neuroprotection
PMID 13374343
Remarkably, pharmacological Se supplementation effectively inhibits GPX4-dependent ferroptotic death as well as cell death induced by excitotoxicity or endoplasmic reticulum (ER) stress, which is GPX4 independent ( The Iron Metabolism-Related Pathway for Ferroptosis Regulation Iron is a redox-active metal that can be engaged in free radical formation and propagation of lipid peroxidation
Cohen PA, Avula B, Wang YH, Katragunta K, Khan I
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