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This has proven effective when applied strategically within -helices, as demonstrated by the periodic substitution of -amino acid residues with corresponding -amino acid residues in the parathyroid hormone inverse agonist, PTH(734)

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Takasu M, Kishi S, Nagasu H, Kidokoro K, Brooks CR, Kashihara N

At the heart of SFNs anti-CSC activity lies its coordinated interference with Wnt/-catenin, Notch, and Hedgehog signaling - three evolutionarily conserved pathways that frequently become dysregulated in CSCs