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Activating SIRT3 in adipocytes could be a potential strategy to alleviate obesity-related metabolic diseases
BMC Genomics 12, 534 (2011)
Storage conditions Store this product in a cool dry place, away from children
Studies show 40% to 50% faster wound closure compared to controls
It was identified through a medicinal chemistry programme at the University of Texas Health Science Center as the lead NNMT inhibitor candidate among a series of 1-methylquinolinium analogues bearing primary amine substitutions, selected for its combination of high passive membrane permeability (confirmed in PAMPA assays), high active transport membrane permeability (confirmed in bidirectional Caco-2 cell assays), potent NNMT inhibitory activity, and high selectivity including confirmed absence of inhibitory effects on related SAM-dependent methyltransferases or enzymes in the NAD+ salvage pathway
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