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Interestingly, GLP-1RA antidiabetic drugs have shown a distinct effect in reducing the incidence of stroke and enhancing neuroprotection in both pre-clinical and clinical studies (80, 81)

288 , E148E154 (2005)

Br J Clin Pharmacol

SHH has previously been identified as a critical signal for the maintenance and renewal of taste cells, while PLC-2 is a marker involved in sweet, umami, and bitter signaling within type II cells, which may contribute to reduced sensitivity to taste stimuli (107)

Helfand, C

Our related article on GLP-1 Signaling, the Microbiome, and Hormones explains why GLP-1 biology is part of a larger metabolic network rather than a stand-alone weight-loss switch