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By incorporating protease-cleavable linkers into drug conjugates, it is possible to achieve a high degree of specificity, minimizing off-target effects and enhancing the therapeutic index of the drug

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However, the FDA has issued a black box warning for thyroid C-cell tumors

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Although preclinical research indicates a favorable safety profile for BPC-157, even at high doses, the lack of comprehensive clinical data necessitates caution in research applications involving this peptide