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actual schedules vary by trial arm and protocol): Starting dose: 2 mg once weekly Escalation: doses increased incrementally (e.g., to 4 mg, 8 mg, and up to 12 mg) at intervals of approximately four weeks Maintenance dose: up to 12 mg once weekly in some trial arms These figures are provided for educational context only and must not be used to guide self-dosing

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June 2021

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In preclinical models, chronic GLP-1 administration improves depression-like behaviors even in lean animals, an effect not mediated by weight loss