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Furthermore, GPX4 deficient mice are associated with increased interstitial oedema and tubular cell death, suggesting a critical role for GPX4 in mediating renal tubular injury (132)

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The brain is well adapted to neutralize oxidative injury by maintaining a high steady-state concentration of small-molecule intracellular antioxidants including glutathione in astrocytes and ascorbic acid in neurons

ARA-290 targets peripheral nerve repair and inflammation through the innate repair receptor, while Dihexa works centrally on synaptic architecture

Human growth hormone-releasing factor (hGRF)1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats

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