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Wat et al

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CB-839 inhibits glutaminase and decreases the viability of HCT-116 cells The SRB assay was used to determine the effect of the glutaminase inhibitor CB-839 on cell viability at doses ranging from 0.1 to 10,000 nM, targeting glutathione inhibition, applied for 48 h in HCT-116 CRC cells

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Other signaling pathways involved in cell dysfunction mTOR can phosphorylate AGC family of protein kinases, regulating cell survival and proliferation