In that setting, particularly among those with underlying heart or kidney disease, the drugs helped improve blood sugar levels, lowered the risk of related complications, aided weight reduction, and reduced the likelihood of early death
However, given the hastened timeline and limited data packages, provider uptake may be low, or payers may implement significant restrictions until real-world benefit is demonstrated
10.1186/s12951-022-01661-w 25 HuJ.LiuS
Phase 2 Side-Effect Frequencies at 4.5 mg/week (Lancet 2021) Side Effect Nausea Incidence at 4.5 mg/week 47% Side Effect Injection-site reactions Incidence at 4.5 mg/week 43% Side Effect Constipation Incidence at 4.5 mg/week 21% Side Effect Fatigue Incidence at 4.5 mg/week 20% Side Effect Allergic reactions (any) Incidence at 4.5 mg/week 10% Side Effect Vomiting Incidence at 4.5 mg/week 8% Side Effect Loose stools Incidence at 4.5 mg/week 7% Side Effect Headache Incidence at 4.5 mg/week 7% Side Effect Indigestion Incidence at 4.5 mg/week 4% Incidence was lower at lower doses
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