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2A and 2B) despite varied basal levels (Fig

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Another oral GLP-1 medicine (oral semaglutide, brand name Rybelsus) was approved previously, but it has strict food and water restrictions at the time of dosing

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Withdrawal behaviors, adapted from Barr et al., 28,32,33 included paw movement, rolling, stretching, body curls, and mild and severe tremors (Table 1), were observed for 30-s intervals every 5 min, and recorded on a checklist