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People with hormone receptor-positive breast cancer lose weight when taking GLP-1s Many people with hormone receptor-positive breast cancer take hormonal therapy to block estrogen from feeding cancer cells
GLP-1 agonists may increase risk through mechanisms including increased intracellular calcium and changes in pancreatic acinar cell signaling, though causality remains under investigation
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According to a review conducted by the European Medicines Agency safety committee in 2025, non-arteritic anterior ischemic optic neuropathy is a very rare side effect of semaglutide that could affect 1 in 10,000 people 33
These logistics are manageable but represent a real difference in daily treatment burden between an oral pill and an injectable biologic
Meanwhile, the higher the dose of the same GLP-1RA preparation, the more likely to cause these adverse reactions
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