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3.3.1 Parkinsons disease (PD) The primary pathologic hallmarks of PD are loss of dopaminergic neurons located in an area of the brain called the substantia nigra pars compacta, and the presence of Lewy bodies, intracellular aggregates of misfolded -synuclein, in dopaminergic neurons and likely contribute to the death of these neurons

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Structural exploration and conformational transitions in MDM2 upon DHFR interaction from Homo sapiens: a computational outlook for malignancy via epigenetic disruption