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In particular, ER UPR-mediated activation of JNK has been linked to the development of insulin resistance and diabetes by inhibition of insulin receptor signaling (131)

This screening should be thorough and appropriate for individual patient risk factors and demographics

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Preliminary neuroimaging studies suggest that GLP-1 agonists may enhance prefrontal cortex connectivity, the brain region responsible for executive functions like planning, working memory, and sustained attention

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