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However it has quickly become famous as a celebrity slimming jab, with online pharmacies prescribing it off-label for those seeking to lose weight

The reasons: Receptor sensitivity: While GHK-Cu doesn't appear to cause receptor downregulation the way some peptides do, cycling is a general precaution to maintain responsiveness and avoid adaptations that might blunt benefits

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Bonini SA, Ferrari-Toninelli G, Uberti D, Montinaro M, Buizza L, Lanni C et al (2011)

The answer to this question came when it was discovered that the TZDs stimulated the expression and release of the adipocyte hormone (adipokine), adiponectin