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14.3 POMC, PCSK1, and LEPR Deficiency (Adults and Pediatric Patients Aged 6 Years and Older) Overview of Clinical Trials The efficacy of IMCIVREE for weight reduction in adults and pediatric patients 6 years of age and older with obesity due to POMC, PCSK1, or LEPR deficiency were assessed in 2 identically designed, 1-year, open-label trials, each with an 8week, double-blind withdrawal period

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If you want to optimise your microneedling protocol: The data suggests that longer treatment duration (36 months minimum) and less aggressive session frequency (fortnightly rather than weekly) may actually produce better results than trying to do more, more often

Long JM, Holtzman DM (2019) Alzheimer disease: an update on pathobiology and treatment strategies