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Alternatively, if the acetylation substrates were to bind to the S1 site a ping pong catalytic mechanism would be likely, i.e., the acetyl group is then transferred from acetyl-CoA to the active site Cys256, forming a covalent acyl-enzyme adduct, and afterwards CoA is released and a substrate protein could bind to S1 site of SnCE1 following acetyl group transfer to the substrates lysine side chain

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Relevant pharmacokinetic parameters for dihexa as determined after IV dosing are summarized in Table 9