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The link between metabolism and epigenetics cannot be ignored in the relationship between mitochondrial abnormalities and T cell exhaustion, providing important insights for the development of new epigenetic strategies to reverse T cell exhaustion and suggesting that the intrinsic effects of mitochondrial metabolism on T cell functional status should be fully considered when designing therapeutic regimens
doi: 10.3389/fendo.2022.1033479 Received 31 August 2022 Accepted 27 October 2022 Published 17 November 2022 Volume 13 - 2022 Edited by Jianbo Zhou, Beijing Tongren Hospital, Capital Medical University, China Reviewed by Finbarr P
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