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The discovery that GHK-Cu binds directly to SIRT1 (Li et al., 2025) has generated particular interest, as SIRT1 is a central regulator of cellular longevity and stress resistance

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MECHANISM CATEGORIES SAFETY Side effects GI: nausea, vomiting (titration-dependent) Injection-site reactions Hypoglycemia risk when combined with insulin Known interactions Insulin additive hypoglycemia risk Contraindications History of MTC or MEN2 (theoretical class effect) REGULATORY STATUS FDA Not yet FDA-approved as of 2026-05