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doi:10.1038/emm.2007.88 Rothstein JD, Dykes-Hoberg M, Pardo CA, Bristol LA, Jin L, Kuncl RW, Kanai Y, Hediger MA et al (1996) Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate

Orforglipron is a single receptor agonist

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This may support more stable appetite suppression and energy balance effects, though weight loss outcomes depend on multiple factors beyond site selection alone

It reduced homocysteine levels

Sample collection and DNA extraction: At the time of sacrifice, cecal contents were collected from a representative subset of four mice per group and immediately stored at -80 C until further analysis