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Additionally, it suppresses glucagon secretion, slows gastric emptying, and acts on appetite centres in the brain to promote feelings of fullness and reduce food intake

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HIC has been used to determine the drug distribution of several ADCs containing auristatin drugs conjugated to inter-chain cysteines (mAb) and engineered cysteines (THIOMAB) through cleavable and noncleavable linkers 4,9-12

A VEGF-independent pathway involving Src kinase and caveolin-1-mediated eNOS activation was additionally proposed as a parallel angiogenic mechanism engaged by BPC157

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