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Butsch clarifies

One clinical trial gives a clearer picture of how often these side effects showed up at higher doses: Dysesthesia refers to unusual or unpleasant skin sensationsthings like tingling, burning, prickling, or a feeling that skin is overly sensitive to touch, sometimes described as a sunburned feeling without any visible cause

At week 26, LDL-C was reduced by 19.0% (-36.0% to -1.9%, p=.029) in the tirzepatide 15 mg group compared to placebo while it was reduced by 17.8% (-33.7% to -2.0%, p= 0.028) in the dulaglutide 1.5 mg group compared to placebo though differences between the 2 medications were not seen [60]

Even though it is rare, GLP1 drugs may increase the risk of pancreatitis and gallstones, especially in those with a history of these conditions