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NAC treatment significantly curbed HFD-induced macrophage infiltration and enhanced the adiponectin gene expression, resulting in improvement of hyperglycemia, hyperinsulinemia, and insulin resistance (Figs

4 While timely recognition and intervention are crucial for mitigating the adverse effects of APAP overdose, effective treatment options are available to manage hepatotoxicity and prevent progression to liver failure

In addition, the degradation of intracellular GPX4 through CMA pathways can lead to the accumulation of intracellular phospholipid peroxide and ferroptosis, and host cells usually use GPX4 for peroxide phospholipids reduction, thus protecting cells from death