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The interplay between insulin resistance, lipotoxicity, chronic inflammation, mitochondrial dysfunction, and gut dysbiosis defines the core molecular framework of MASLD pathogenesis, as illustrated in a comprehensive mechanistic model (Figure 2)

How to Safely Manage GLP-1 Discontinuation If you decide to stop GLP-1 therapy with your provider's guidance, gradual tapering rather than abrupt cessation may ease the transition

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PMID 17927283

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These inflammatory mediators also compromise the BTB, leading to cell damage and apoptosis during spermatogenesis [272,273,274,275]