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PPARa Regulates the FSP1-CoQ10-NAD(P)H Pathway to Protect Neurons from Ferroptosis in TSCI Mice, Promoting Neuronal Survival and Motor Function Recovery Having confirmed that PPARa regulates FSP1 transcription and mitigates lipid peroxidation through the FSP1-CoQ10-NAD(P)H pathway in vitro, we sought to determine whether this mechanism could improve neuronal survival and functional recovery following TSCI in vivo

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doi: 10.1038/s41420-024-02137-6 149 XueWJianWMengYWangTCaiLYuYet al