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The liver contains GLP-1 receptors, and activation appears to directly reduce hepatic lipogenesis (fat production in the liver), increase fatty acid oxidation, and reduce inflammatory signaling in hepatocytes

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Two of these clusters are particularly aggressive

Safety, Provider Oversight, and Who Should Consider HSA-Funded GLP-1 Therapy GLP-1 medications are appropriate for individuals with a BMI of 30 or higher, or BMI of 27+ with comorbidities like hypertension or type 2 diabetes

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A thorough medical evaluation is required before starting therapy