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Results We show that our model accurately reproduces published clinical and experimental data on the dose-dependent time course of acetaminophen in the plasma, the accumulation of acetaminophen and its metabolites in the urine, and the depletion of glutathione caused by conjugation with the toxic product

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The collagen timeline reflects findings from the Frontiers in Nutrition 2025 trial, where 180 days of supplementation produced statistically significant WOMAC improvements

doi:10.1530/eje.0.1390552 Khorram O, Laughlin GA, Yen SSC