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Spravato is currently the only FDA-approved ketamine-based therapy for depression and is covered by most major insurance plans , making it accessible for many patients seeking advanced treatment options

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Most people tolerate this level well

Medications for the treatment of dopaminergic symptoms include encompassing DA replacement therapy, peripheral 3,4-Dihydroxyphenylalanine (DOPA) decarboxylase inhibitors (DCI), DA receptor (DR) agonists, MAO-B inhibitors, and catechol-O-methyltransferase (COMT) inhibitors

Interestingly, except for increased pyruvate accumulation and DHAP and Gro3P consumption, metabolites comprising glycolysis remained largely unaffected by Cr GPDH expression ( Figure 3d )

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