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Nitric oxide and substance dependence

First, regarding lactate metabolism, hypoxia and mitochondrial damage induce a shift toward glycolysis for compensatory ATP production, potentially leading to lactate accumulation (90, 91)

However, Phase 3 trials did not demonstrate sufficient efficacy for regulatory approval, and development was discontinued

Am J Physiol Gastrointest Liver Physiol 306(1):G48-58, 2014

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