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GLP-1 also signals to the brain to reduce appetite and slow down the rate of food digestion, which can lead to weight loss

Side effects can persist after a dose change Because GLP1 levels taper gradually rather than dropping to zero, symptoms can continue for days or even weeks after a dose change

New insights into GLP-1 receptor agonists for the treatment of obesity

Previous studies demonstrated that the proliferative and antiapoptotic efficacy of GLP-1RAs, in particular of exendin-4, is mediated by the increased expression of IRS-2 as well as the activation of Akt, key downstream effectors of both insulin (IR) and IGF-1 receptor (IGF-1R) signaling (38)

Refrigerate unused GLP-1 medication (36F to 46F [2C to 8C]), but not near the cooling element

GLP-1s slow how quickly the stomach releases food into the small intestine