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Both adipokines are increased in MASLD patients especially those with obesity and thus play a role in disease progression

Importantly, tricyclic antidepressants, especially amitriptyline and nortriptyline, worsen the metabolic profile, increasing insulin resistance, contributing to weight gain and causing hyperglycemia, thereby increasing the risk of diabetes with prolonged use [77]

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This is important in laboratory studies, as LPS can interfere with experimental outcomes and immune-response measurements in research models

Resting-state fMRI studies have demonstrated significantly reduced DMN coherence in both current and recovered patients, suggesting a trait-level disturbance in how internal narrative and bodily self-image are integrated (Scaife et al., 2017)