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Inhibition of LDHA can enhance T-cell-mediated immune surveillance against tumors

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In line with this theory, familial hemiplegic migraine type 2 (FHM2) mice, who are genetically predisposed to migraine, have been shown to have lower GABA and higher glutamate levels in the thalamus compared to wild-type mice 31

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Activation of gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis