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The theory is that smaller, more frequent doses maintain receptor stimulation at a level that avoids heavy desensitization while preserving beneficial effects
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There have been reports of people accidentally taking a much larger dose than intended of compounded semaglutide or tirzepatide, leading to side effects like nausea, vomiting, and diarrhea sometimes so severe that they required hospitalization
Pendulum GLP-1 Probiotic Pendulum GLP-1 Probiotic uses live bacterial strains, including Akkermansia muciniphila, which has more published research supporting its role in metabolic health and GLP-1 modulation than the RSB11 strain in resM
Still, a trial result is not the same as broad approval, and trial dosing information is not a dosing guide for use outside the study
PMID: 11014225
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